Every month, new developments in the field of induced pluripotent (iPS) stem cells are published in the literature. Reprogramming adult human cells without the use of agents that could cause cancer is the first hurdle. To introduce the reprogramming gene into cells, the first method of reprogramming used a virus delivery system.
A virus can insert itself into a cell's DNA, potentially causing cancer. It is also necessary to refine the reprogramming parameters. The original group consisted of the Oct-4, Sox2, c-Myc, and Klf4 genes. C-Myc is a powerful oncogene – c-Myc expression that can cause cancerous cells to develop. c-Myc was first discovered in the late 1970s.
It plays a major role in breast cancer development and is involved in many types of human malignancies. These cells could be safely used in humans if there were reprogramming options to c-Myc. The best scenario is to find alternatives to any given gene that can be used for reprogramming. You can find out about regenerative medicine through https://5linebiologics.com/ and use it as a great alternative for treatment.
Injecting new genes into cells could cause mutations and disrupt other genetic processes. As cells and tissues continue to multiply and reproduce, these deleterious effects will increase in severity and number. This field is rapidly moving forward. Many researchers have successfully investigated the potential use of small molecules to reprogramme genes.
The smallest molecules are those with very short nucleotide segments, peptides, and short-chain sugars. A team created induced pluripotent stem cell lines using direct delivery of small molecules that were reprogrammed. This innovative work has the potential to create safer cells for transplantation and treatment.